Arterial Stiffness in Patients Taking Second-generation Antipsychotics
Clinical Psychopharmacology and Neuroscience
;
: 365-370, 2016.
Article
in English
| WPRIM
| ID: wpr-210155
ABSTRACT
OBJECTIVE:
That treatment with second-generation antipsychotics (SGAs) causes metabolic side effects and atherosclerosis in patients with schizophrenia and bipolar disorder (BD) is well-known. Increased arterial stiffness is an important marker of arteriosclerosis and has been identified as an independent risk factor for cardiovascular diseases. We measured pulse wave velocity (PWV) as a marker of arteriosclerosis in patients with schizophrenia and BD who use SGAs.METHODS:
Patients and controls were collected from our psychiatry outpatient clinics or family medicine. Mental illness was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Mean age, gender, systolic and diastolic blood pressure, body mass index, Framingham risk score (FRS), etc. were determined. Simultaneous electrocardiography and pulse wave were recorded with an electromyography device. The photo-plethysmographic method was used to record the pulse wave. Inclusion criteria included use of SGAs for at least the last six months. Patients with diseases that are known to cause stiffness and the use of typical antipsychotics were excluded.RESULTS:
Ninety-six subject (56 patients, 40 controls) were included in our study. There were 49 females, 47 males. Patients had schizophrenia (n=17) and BD (n=39). Their treatments were quetiapine (n=15), risperidone (n=13), olanzapine (n=15), and aripiprazole (n=13). Although differences in mean age, gender, and FRS in the patient and control groups were not statistically significant (p=1), PWV was greater in patients in the antipsychotic group (p=0.048).CONCLUSION:
This study supported the liability to stiffness in patients with schizophrenia and BD. Using SGAs may contribute to arterial stiffness in these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arteriosclerosis
/
Schizophrenia
/
Antipsychotic Agents
/
Bipolar Disorder
/
Blood Pressure
/
Cardiovascular Diseases
/
Body Mass Index
/
Risk Factors
/
Risperidone
/
Diagnostic and Statistical Manual of Mental Disorders
Type of study:
Etiology study
/
Practice guideline
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2016
Type:
Article
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