Clinical Model for Predicting Hepatocellular Carcinomas in Patients with Post-Sustained Virologic Responses of Chronic Hepatitis C: A Case Control Study
Gut and Liver
;
: 955-961, 2016.
Article
in English
| WPRIM
| ID: wpr-210173
ABSTRACT
BACKGROUND/AIMS:
No clinical model exists to predict the occurrence of hepatocellular carcinoma in sustained virologic response-achieving (HCC after SVR) patients with chronic hepatitis C (CHC).METHODS:
We performed a case-control study using a clinical database to research the risk factors for HCC after SVR. A predictive model based on risk factors was established, and the area under the receiver operating characteristic curve (AUC) was calculated.RESULTS:
In the multivariate model, an initial diagnosis of compensated cirrhosis and post-SVR albumin reductions of 1 g/L were associated with 21.7-fold (95% CI, 4.2 to 112.3; p0, an AUC of 0.880, a sensitivity of 0.833, a specificity of 0.896, and a negative predictive value of 0.956.CONCLUSIONS:
An initial diagnosis of compensated cirrhosis combined with a post-SVR albumin value of ≤36.0 g/L predicts the occurrence of HCC after SVR in patients with CHC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
Case-Control Studies
/
Risk Factors
/
ROC Curve
/
Sensitivity and Specificity
/
Carcinoma, Hepatocellular
/
Area Under Curve
/
Hepatitis C, Chronic
/
Diagnosis
/
Hepatitis, Chronic
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2016
Type:
Article
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