Contrast-Enhanced Harmonic Ultrasonography for the Assessment of Prostate Cancer Aggressiveness: a Preliminary Study
Korean Journal of Radiology
;
: 75-83, 2010.
Article
in English
| WPRIM
| ID: wpr-21020
ABSTRACT
OBJECTIVE:
To determine whether contrast-enhanced harmonic ultrasonography can be used to predict the aggressiveness of prostate cancer. MATERIALS ANDMETHODS:
Contrast-enhanced harmonic ultrasonography was performed in 103 patients suspected of prostate cancer before biopsy. Time intensity curves were reconstructed for systematic biopsy sites and sonographic abnormalities. The characteristics of the curves were described using hemodynamic indices including arrival time (AT), time-to-peak (TTP), and peak intensity (PI). The differences of hemodynamic indices between high-grade and low-grade cancer were analyzed and the correlations between the hemodynamic indices and biopsy Gleason score were studied.RESULTS:
Prostate cancer was detected in 41 of 103 patients and there were significant differences in the hemodynamic indices between the biopsy sites of the non-malignant patients and prostate cancer lesions (p < 0.05). The prostate biopsies revealed 154 prostate cancer lesions, including 31 low-grade lesions and 123 high-grade lesions. The hemodynamic indices AT and TTP of high-grade tumors were significantly shorter than those of low-grade tumors (p = 0.001, 0.002). In addition, high-grade peripheral zone (PZ) tumors had higher PI than low-grade PZ tumors (p = 0.009). The PZ prostate cancer Gleason score correlated with PI, AT and TTP, with Spearman correlation coefficients of 0.223, -0.335, and -0.351, respectively (p = 0.013, < 0.001 and < 0.001).CONCLUSION:
Contrast-enhanced ultrasound measurements of hemodynamic indices correlate with the prostate cancer Gleason score.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phospholipids
/
Prostate
/
Prostatic Neoplasms
/
Sulfur Hexafluoride
/
Biopsy, Needle
/
Ultrasonography, Interventional
/
Ultrasonography, Doppler
/
Contrast Media
/
Hemodynamics
Type of study:
Prognostic study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Radiology
Year:
2010
Type:
Article
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