The Comparison of Interferon-alpha Treatment by Dosages and Retreatment for Chronic Hepatitis B in Children / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition
;
: 152-160, 2003.
Article
in Korean
| WPRIM
| ID: wpr-210367
ABSTRACT
PURPOSE:
We compared the therapeutic efficacy of low dose with that of standard dose of interferon (IFN) treatment and also compared the first IFN treatment with retreatment.METHODS:
We have studied 51 children (age, 2~14) treated for chronic hepatitis B from March 1990 to August 1999. Twenty seven children had been treated with 3 MU/m2 (2.66+/-0.66 MU/m2) of IFN-alpha three times a week for 6 months (range, 6~12 months), whereas 24 children with 6 MU/m2 (4.45+/-0.94 MU/m2). There was no significant difference in gender, age, initial ALT and HBV DNA levels between each comparative group.RESULTS:
Among the 27 children treated with 3 MU/m2 of IFN, ALT level had normalized in 11 children (41%) and anti-HBe seroconversion occurred in 9 children (33%) one year after the initiation of treatment. In comparison, among the 24 children treated with 6 MU/m2 of IFN, ALT normalized in 12 children (50%) and anti-HBe seroconversion occurred in 7 children (29%). In comparing the first treatment group to retreatment group, ALT level had normalized in 23 children (45%) and anti-HBe seroconversion occurred in 16 children (31%) among the 51 children treated with the first course of IFN treatment. In comparison, ALT normalized and anti-HBe seroconversion occurred in 3 children (25%) among the retreated 12 children.CONCLUSION:
There was no significant difference in the therapeutic efficacies between 3 MU/m2 and 6 MU/m2 dose of IFN treated groups in ALT normalization and anti-HBe seroconversion. The retreatment efficacy of IFN-alpha was as effective as the first treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
Interferons
/
Interferon-alpha
/
Retreatment
/
Hepatitis B, Chronic
/
Hepatitis, Chronic
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatric Gastroenterology and Nutrition
Year:
2003
Type:
Article
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