Long Term Follow Up of Interferon-alpha Treatment in Children with Chronic Hepatitis B / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition
;
: 140-151, 2003.
Article
in Korean
| WPRIM
| ID: wpr-210368
ABSTRACT
PURPOSE:
We tried to evaluate the long term efficacy and positive predictive factors of interferon-alpha treatment in children with chronic hepatitis B.METHODS:
The study population included 113 children who received interferon therapy between May 1982 and July 2002 (20 years) for chronic hepatitis B in Department of Pediatrics, Yonsei University College of Medicine. Male to female ratio was 2.31 and the mean age at diagnosis was 11.1+/-4.1 years old. Response to treatment was defined as normalization of alanine aminotransferase (ALT), disappearance of HBeAg and HBV-DNA Eighty two children responded while 32 did not. Interferon-alpha was given intramuscularly for 6 months at a dosage of 3x106 unit, 3 times weekly. In relapsed cases, lamivudine or interferon retreatment was done.RESULTS:
Seroconversion rate was 77.0% in terms of HBeAg, 74.3% in terms of HBV-DNA, and 80.5% in terms of ALT normalization after treatment. Seroconversion rate of both HBeAg and HBV-DNA was 72.6%. Analyzed by life table method, the effect of the treatment had been maintained over 10 years after cessation of therapy. Pre-treatment ALT level was the only significant positive predictive factor of response. Eleven cases (13.4%) relapsed, and 2 out of 3 showed response when treated with lamivudine and 1 out of 3 with interferon retreatment.CONCLUSION:
Interferon-alpha showed significant efficacy in the treatment of chronic hepatitis B in our study. Further studies about the effect of interferon therapy on complications of hepatitis such as hepatocarcinoma, cirrhosis are warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Fibrosis
/
Follow-Up Studies
/
Life Tables
/
Interferons
/
Interferon-alpha
/
Lamivudine
/
Retreatment
/
Hepatitis B, Chronic
/
Diagnosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Pediatric Gastroenterology and Nutrition
Year:
2003
Type:
Article
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