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Polymeric Gene Delivery for Diabetic Treatment
Diabetes & Metabolism Journal ; : 317-326, 2011.
Article in English | WPRIM | ID: wpr-210390
ABSTRACT
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmids / Polyethylene Glycols / Polylysine / Polymers / DNA / RNA, Messenger / Mice, Inbred NOD / Interleukin-10 / Transplants / RNA, Small Interfering Limits: Animals Language: English Journal: Diabetes & Metabolism Journal Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmids / Polyethylene Glycols / Polylysine / Polymers / DNA / RNA, Messenger / Mice, Inbred NOD / Interleukin-10 / Transplants / RNA, Small Interfering Limits: Animals Language: English Journal: Diabetes & Metabolism Journal Year: 2011 Type: Article