Effect of Antioxidants on FeSO4 Toxicity in Cultured Myocardial Cells / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 161-168, 1997.
Article
in Korean
| WPRIM
| ID: wpr-210482
ABSTRACT
In order to elucidate the cardiotoxicity of FeSO4 in cultured myocardial cells derived from neonatal rat, cardiotoxicity was measured by MTT assay when cultured cells were treated with various concentrations of FeSO4. In addition, the cardioprotective effect of antioxidants, glutathione and ascorbic acid was evaluated by MTT assay in these cultrures. Cell viability was remakably decreased in a dose -dependent manner after exposure of cultured rat myocardial cells to 20 microM FeSO4 for 48 hours. In the cardioprotective effect of antioxidants on FeSO4 -induced toxicity, glutathione blocked the cardiotoxicity induced by FeSO4, while ascorbic acid was not effective in blocking FeSO4 -induced cardiotoxicity in these cultures. These results suggest that FeSO4 is toxic in cultured myocardial cells from neonatal rat and selective antioxidants such as glutathione are effective in blocking the cardiotoxicity induced by FeSO4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ascorbic Acid
/
Cell Survival
/
Cells, Cultured
/
Glutathione
/
Antioxidants
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Physical Anthropology
Year:
1997
Type:
Article
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