Blastoid Mantle Cell Lymphoma: A Case Report / 대한피부과학회지
Korean Journal of Dermatology
;
: 684-688, 2010.
Article
in Korean
| WPRIM
| ID: wpr-210549
ABSTRACT
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually as a manifestation of disseminated disease. The immunophenotype of MCL is characterized as CD20+, CD5+ and Cyclin D1+. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. In the blastoid variant, the genetic profile is often more complex and includes tetraploid chromosomes, CCND1 amplification, a higher incidence of p53 gene mutations, and p16(INK4a) deletions. We report a case of a 62-year-old male patient who presented with erythematous subcutaneous nodules on the lower back. He had been treated for BV-MCL of the testis which had occurred 1 year ago. The analysis of histopathological and immunohistochemical examinations of the skin lesions also revealed a BV-MCL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Testis
/
B-Lymphocytes
/
Incidence
/
Genes, p53
/
Cyclins
/
Cyclin-Dependent Kinase Inhibitor p16
/
Lymphoma, Mantle-Cell
/
Tetraploidy
/
Lymphoma
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2010
Type:
Article
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