Clinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea / 대한피부과학회지
Korean Journal of Dermatology
;
: 665-671, 2010.
Article
in Korean
| WPRIM
| ID: wpr-210552
ABSTRACT
BACKGROUND:
Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy.OBJECTIVE:
The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream.METHODS:
In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions.RESULTS:
During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild.CONCLUSION:
This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinolizines
/
Skin
/
Acne Vulgaris
/
Fluoroquinolones
/
Republic of Korea
/
Korea
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2010
Type:
Article
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