A histopathologic study of congential melanocytic nevi / 대한피부과학회지
Korean Journal of Dermatology
;
: 523-531, 1993.
Article
in Korean
| WPRIM
| ID: wpr-210738
ABSTRACT
BACKGROUND:
since congenital nevi may not always be identified clirically, it remains a challange for histologists to separate an acquired from a congehital nevus. The camparative histologic feature of congenital and acquired lesions have been described by several authors.OBJECTIVE:
In an attempt to establish reliable microscopic recognition of congenital nevi, the histologic features of 52 congenital melanocytic nevi were studied. MATERIAL ANDMETHODS:
By reviewing HMB slides, histologic paterns were observed depending on the extent of nevus cell infiltration. An immunohistochemical study wi h anti S-100 protein and HMB-45 antibody was also performed.RESULTS:
Diffuse infiltratien of upper and lower dermis with nevu. cells was observed in 21 cases (40.0%). Nevus cell infiltration of appendages and neurovascular structures was observed in 29 cases (55.8%). Indian filing of dermal nevus cells was observed in 33 casesl(64.7%). Epidermis showed elongation of rete ridges in 36 ca.es(69.2%). Immunohistochemical staining with HMB 45 showed a positive raction in 9 cases out of 51 having dermal nevus cells, and epidemal melanocytes showed positive reaction in 20 cases.CONCLUSION:
Congenital melanocytie nevi can be classified by histolcgic appearance into several patterns. Nevus cells had a trend to infiltrate into the deeper dermis as the clinieal size increrased. Nevus cell infiltration of appendages and neurovascular structure was a common finding in congenital melanocytic nevi.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
S100 Proteins
/
Dermis
/
Epidermis
/
Melanocytes
/
Nevus
/
Nevus, Pigmented
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1993
Type:
Article
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