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A Phase II Study of Weekly Paclitaxel Plus Gemcitabine as a Second-Line Therapy in Patients with Metastatic or Recurrent Small Cell Lung Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 465-472, 2016.
Article in English | WPRIM | ID: wpr-210750
ABSTRACT

PURPOSE:

Paclitaxel (P) and gemcitabine (G) are clinically synergistic in small cell lung cancer (SCLC). We evaluated the efficacy of PG as a salvage treatment for SCLC patients whose disease progressed after a platinum-containing regimen. MATERIALS AND

METHODS:

Eligibility included histologically confirmed SCLC, one dimensionally measurable disease, Eastern Cooperative Oncology Group performance status 0-2, and progressive disease after platinum-based chemotherapy. Treatment consisted of P (80 mg/m2) and G (1,000 mg/m2) on days 1 and 8 of each cycle of 21 days until disease progression.

RESULTS:

Thirty-three patients seen between December 2005 and February 2009 were selected into this study. Thirty patients (91%) had received irinotecan-platinum, and three had received etoposide-platinum. Sixteen patients (49%) had a treatment-free interval of less than 3 months. The overall response rate was 30.3% (29.4% in sensitive relapse and 31.3% in refractory relapse). The median time to progression was 12.0 weeks and median overall survival (OS) 31.0 weeks, with a 1-year OS rate of 30.3%. Toxicities were moderate and manageable with 18.2% grade (G) 4 neutropenia, 24.2% G3 thrombocytopenia, 6.1% G3 sensory neuropathy, and 3% G3 asthenia. One patient developed febrile neutropenia.

CONCLUSION:

Second-line paclitaxel and gemcitabine were well-tolerated and moderately active in SCLC patients previously treated with platinum-based chemotherapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Asthenia / Thrombocytopenia / Paclitaxel / Disease Progression / Drug Therapy / Small Cell Lung Carcinoma / Febrile Neutropenia / Neutropenia Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Asthenia / Thrombocytopenia / Paclitaxel / Disease Progression / Drug Therapy / Small Cell Lung Carcinoma / Febrile Neutropenia / Neutropenia Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article