Molecular variants of the FSH receptor exon 10 (Thr307Ala; A919G) in premature ovarian failure (POF) women by PCR-SSCP / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1144-1146, 2000.
Article
in Korean
| WPRIM
| ID: wpr-210841
ABSTRACT
OBJECTIVE:
This study was performed to determine whether the FSH receptor mutation is present in infertile Korean patients with 46,XX premature ovarian failure (POF) women.METHODS:
The variant of FSH receptor exon 10 in thirteen 46, XX idiopathic POF and 4 healthy fertile (control) women were studied. Missense mutation in Exon 10 was detected in POF patients and healthy fertile women by polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP).RESULTS:
The variant types of FSH receptor exon 10 (Thr307Ala; A919G) were found in healthy fertile (control) and POF women.CONCLUSIONS:
This mutation may not be specific in POF patients and further study is needed in fertile (control) and POF women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, FSH
/
Exons
/
Primary Ovarian Insufficiency
/
Mutation, Missense
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2000
Type:
Article
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