Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 550-555, 2007.
Article
in Korean
| WPRIM
| ID: wpr-21120
ABSTRACT
BACKGROUND:
Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery.METHODS:
In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation.RESULTS:
The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P < 0.05). There were no significant differences between groups in adverse events.CONCLUSIONS:
Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vomiting
/
Midazolam
/
Incidence
/
Prospective Studies
/
Postoperative Nausea and Vomiting
/
Ketorolac
/
Ear, Middle
/
Anesthesia
/
Metoclopramide
/
Antiemetics
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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