Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates
Journal of Pathology and Translational Medicine
;
: 318-324, 2015.
Article
in English
| WPRIM
| ID: wpr-211238
ABSTRACT
BACKGROUND:
Macrophages are a component of a tumor's microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers.METHODS:
We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry.RESULTS:
Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0+/-3.5%, 6.9+/-7.4%, and 6.9 +/- 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 +/- 1.6% vs anaplastic, 22.9 +/- 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers.CONCLUSIONS:
Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Prognosis
/
Thyroid Gland
/
Breast
/
Thyroid Neoplasms
/
Survival Rate
/
Gallbladder
/
Gallbladder Neoplasms
/
Korea
/
Lung
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2015
Type:
Article
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