Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
Journal of Pathology and Translational Medicine
;
: 310-317, 2015.
Article
in English
| WPRIM
| ID: wpr-211239
ABSTRACT
BACKGROUND:
Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients harboring the EML4/ALK translocation. However, using ALK-fluorescence in situ hybridization (FISH) as the standard method has demerits such as high cost, a time-consuming process, dependency on interpretation skill, and tissue preparation. We analyzed the histologic findings which could complement the limitation of ALK-FISH test for pulmonary adenocarcinoma.METHODS:
Two hundred five cases of ALK-positive and 101 of ALK-negative pulmonary adenocarcinoma from January 2007 to May 2013 were enrolled in this study. The histologic findings and ALK immunohistochemistry results were reviewed and compared with the results of ALK-FISH and EGFR/KRAS mutation status.RESULTS:
Acinar, cribriform, and solid growth patterns, extracellular and intracellular mucin production, and presence of signet-ring-cell element, and psammoma body were significantly more often present in ALK-positive cancer. In addition, the presence of goblet cell-like cells and presence of nuclear inclusion and groove resembling papillary thyroid carcinoma were common in the ALK-positive group.CONCLUSIONS:
The above histologic parameters can be helpful in predicting ALK rearranged pulmonary adenocarcinoma, leading to rapid FISH analysis and timely treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Complement System Proteins
/
Thyroid Neoplasms
/
Immunohistochemistry
/
Adenocarcinoma
/
In Situ Hybridization, Fluorescence
/
In Situ Hybridization
/
Carcinoma, Non-Small-Cell Lung
/
Intranuclear Inclusion Bodies
/
Lung
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2015
Type:
Article
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