Acute Liver Failure Associated with Occupational Exposure to Tetrachloroethylene
Journal of Korean Medical Science
;
: 138-142, 2011.
Article
in English
| WPRIM
| ID: wpr-211268
ABSTRACT
Tetrachloroethylene is a chlorinated solvent that is primarily used in dry cleaning and degreasing operations. Although the hepatotoxicity caused by tetrachloroethylene has been well documented in literature, it is rarely considered as a cause of acute liver failure. We report a case of a 39-yr-old man who was admitted to our hospital for acute liver failure due to tetrachloroethylene exposure. Histological examination of the liver revealed massive hepatic necrosis, prominently, in zone 3 of the hepatic lobules. The patient underwent supportive treatment along with 3 sessions of plasmapheresis, and consequently, he presented a favorable outcome. Repeat liver biopsy performed 6 months after the patient's discharge showed architectural distortion with postnecrotic cirrhosis. Physicians should be aware of the possibility of acute liver failure induced by tetrachloroethylene. Early plasmapheresis can be effective for individuals with sufficient capacity for hepatocyte regeneration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tetrachloroethylene
/
Carcinogens
/
Occupational Exposure
/
Plasmapheresis
/
Liver Failure, Acute
/
Liver Cirrhosis
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Type:
Article
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