Enhancement of Human Monocyte Activities against Aspergillus fumigatus by Interleukin-15 / 대한의진균학회지
Korean Journal of Medical Mycology
;
: 64-69, 2001.
Article
in Korean
| WPRIM
| ID: wpr-211352
ABSTRACT
BACKGROUND:
Despite recent advances in antifungal chemotherapy, invasive aspergillosis remains an important cause of morbidity and mortality in immunocompromised patients. Interleukin-15 (IL-15) is a cytokine that is known to enhance antifungal activities of monocytes against Candida albicans.OBJECTIVE:
The purpose of this study is to investigate the potentials of IL-15 to enhance antifungal activities of monocytes against Aspergillus fumigatus.METHODS:
Peripheral blood monocytes from healthy adults were incubated with 0, 1, 10, 100 ng/ml of IL-15 for 1, 2, and 4 days. Then, the ability of IL-15 to elicit the production of superoxide anion, the damage of hyphae by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the killing ability of Aspergillus fumigatus conidia was investigated.RESULTS:
Incubation of peripheral blood monocytes with 100 ng/ml of IL-15 enhanced hyphal damage after 2 days (p<0.05), conidicidal activity from the first day (p<0.05), and increased the production of superoxide anion (O2- ) in response to phorbol myristate acetate.CONCLUSION:
Our results indicate that IL-15 augments the microbicidal activity of human monocytes against Aspergillus fumigatus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspergillosis
/
Aspergillus
/
Aspergillus fumigatus
/
Spores, Fungal
/
Candida albicans
/
Tetradecanoylphorbol Acetate
/
Monocytes
/
Mortality
/
Immunocompromised Host
/
Superoxides
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Medical Mycology
Year:
2001
Type:
Article
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