The Expression of High Mobility Group I (Y) Proteins in Human Breast Cancer / 한국유방암학회지
Journal of Korean Breast Cancer Society
;
: 1-5, 2001.
Article
in Korean
| WPRIM
| ID: wpr-211483
ABSTRACT
PURPOSE:
The precise mechanisms of tumorigenesis of breast cancer remains unknown in spite of major efforts. Recent studies have shown that High Mobility Group I (Y) Proteins [HMGI(Y)] have an important role in the regulation of chromatin structure and function, and that HMGI(Y) protein expression is generally correlated with a malignant phenotype. This study was undertaken to define the relationship of the HMGI(Y) protein expression between malignant breast tissue and non-malignant breast tissue in human, and clinico- pathologic findings were reviewed for this purpose.METHODS:
Using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for HMGI(Y) with beta-actin, this study demonstrated the expression of HMGI(Y). The p53, ER, and PR. were defined by immunohistochemical staining.RESULTS:
The HMGI(Y) expression was increased in the malignant tissue (90%), than in benign (76.9%) or normal (65%) tissue (p=0.031). As for the invasive ductal cancers, there was no difference between the HMGI(Y) expression and histopathologic parameters.CONCLUSION:
These results suggest that the HMGI(Y) expression may be of little pathogenetic prognostic importance in human breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Breast
/
Breast Neoplasms
/
Chromatin
/
Actins
/
Carcinogenesis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Breast Cancer Society
Year:
2001
Type:
Article
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