Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 151-156, 2012.
Article
in English
| WPRIM
| ID: wpr-21153
ABSTRACT
Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Biology
/
Drug Resistance
/
Incidence
/
Epithelial-Mesenchymal Transition
/
Lung
/
Lung Neoplasms
/
Morphogenesis
/
Neoplasm Metastasis
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2012
Type:
Article
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