Hyperhomocysteinemia as a Risk Factor for Cerebral Infarction / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 234-240, 2005.
Article
in Korean
| WPRIM
| ID: wpr-211871
ABSTRACT
BACKGROUND:
Homocysteine (Hcy) is known to increase the risk of cerebrovascular disease. I investigated this association in cerebral infarction (CI) and established reference intervals for serum total Hcy concentrations among individuals aged 40 or over in Korea.METHODS:
I measured Hcy concentrations in the sera from 93 healthy controls (male 74, female 19) and 742 patients with CI (male 616, female 126) by a fluorescent polarization immuno assay technique using Axsym system (Abbott Laboratories, IL, USA).RESULTS:
In CI group, the following parameters were significantly higher (P or =60 years), hypertension, DM, hyperhomocysteinemia, high creatinine, and in the highest Hcy quartile (> or =15.1 micromol/L) compared to the lowest Hcy quartile (<9.6 micromol/L) with the crude odds ratios of 2.1, 4.3, 10.5, 7.4, 3.0, and 6.6, respectively; in multivariate analysis, the risk of CI was independently associated with hypertension, DM, hyperhomocysteinemia and adjusted odds ratios were 3.6, 5.3, and 7.1, respectively. In CI group, Hcy exhibits negative correlations (P<0.001) with folate (r=-0.356) and vitamin B12 (r=-0.256).CONCLUSIONS:
Hyperhomocysteinemia may represent an independent risk factor for cerebrovascular disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vitamin B 12
/
C-Reactive Protein
/
Odds Ratio
/
Cerebral Infarction
/
Prevalence
/
Multivariate Analysis
/
Risk Factors
/
Hyperhomocysteinemia
/
Creatinine
/
Diabetes Mellitus
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2005
Type:
Article
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