Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
Experimental & Molecular Medicine
; : 536-544, 2012.
Article
in En
| WPRIM
| ID: wpr-211933
Responsible library:
WPRO
ABSTRACT
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2 inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pyrazoles
/
Sulfonamides
/
Catalysis
/
Skin Aging
/
Aspirin
/
Gene Expression Regulation
/
Tumor Suppressor Protein p53
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Collagen Type I
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Cyclooxygenase 2
/
Caveolin 1
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2012
Type:
Article