Preoperative constipation is associated with poor prognosis of rectal cancer: a prospective cohort study / 대한외과학회지
Journal of the Korean Surgical Society
;
: 35-42, 2013.
Article
in English
| WPRIM
| ID: wpr-211940
ABSTRACT
PURPOSE:
It is unknown whether patients with advanced rectal cancer develop severe constipation. Therefore, the objective of this study was to assess whether constipation severity is associated with pathologic progression of rectal cancer.METHODS:
We analyzed 472 patients with rectal cancer who underwent elective surgical resection between January 2005 and December 2010. Constipation severity was prospectively evaluated in 407 patients (86.2%) using the Cleveland Clinic Constipation Score System. Linear regression analysis was performed to identify clinicopathologic variables associated with constipation. Kaplan-Meier analysis and Cox proportional hazard models were used to evaluate the prognostic value of constipation severity on disease-free and overall survival.RESULTS:
Multivariable analysis showed that sex (regression coefficient [B] = 1.55; 95% confidence interval [CI], 0.79 to 2.60; P or = 8) was independently associated with 3-year disease-free survival (vs. scores of 0-3; hazard ratio [HR], 2.39; 95% CI, 1.15 to 4.98; P = 0.020) and 5-year overall survival (HR, 2.30; 95% CI, 1.23 to 4.30; P = 0.009) in multivariable analysis.CONCLUSION:
Our results suggest that preoperative constipation severity is associated with advanced pathologic stage and poor oncologic outcomes in patients with rectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Rectal Neoplasms
/
Body Mass Index
/
Linear Models
/
Proportional Hazards Models
/
Prospective Studies
/
Surveys and Questionnaires
/
Cohort Studies
/
Disease-Free Survival
/
Constipation
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Surgical Society
Year:
2013
Type:
Article
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