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Clinical implications of preoperative thyrotropin serum concentrations in patients who underwent thyroidectomy for nonfunctioning nodule(s) / 대한외과학회지
Journal of the Korean Surgical Society ; : 15-19, 2013.
Article in English | WPRIM | ID: wpr-211944
ABSTRACT

PURPOSE:

Thyroid stimulating hormone (TSH) measurement is the most sensitive screening test for thyroid dysfunction. TSH is a well-known thyroid growth factor but its pathogenic role in thyroid oncogenesis remains to be clarified. The purpose of the present study was to evaluate the relationship between clinicopathologic characteristics of nonfunctioning thyroid nodules and preoperative TSH serum concentrations.

METHODS:

Serum TSH concentrations can be affected by many factors. After exclusion of these confounding factors, a total of 126 patients who underwent thyroidectomy from Januray 2009 to December 2010 were included in this study. Average age was 45.4 +/- 10.6 years and malefemale ratio was 12.9. There were 11 patients with benign nodules, 34 patients with papillary thyroid microcarcinoma (PTMC) of less than 5 mm in maximal diameter, 66 patients with PTMCs of more than 5 mm but not more than 10 mm in maximal diameter, and 15 patients with papillary thyroid carcinoma (PTC) of more than 10 mm in maximal diameter.

RESULTS:

TNM stages of PTCs correlated with higher preoperative TSH serum concentrations. There were trends of higher preoperative TSH serum concentrations in patients who had extrathyroidal extension (P = 0.059) and advanced N stages (P = 0.120) but did not reach statistical significance. Patients' age, sex, and tumor volume did not seem to affect preoperative TSH serum concentrations significantly.

CONCLUSION:

In patients who have PTCs without clinical, immunological, or ultrasonographic evidence of thyroiditis, higher preoperative TSH serum concentrations within the normal range might suggest advanced TNM stages.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Values / Thyroid Gland / Thyroidectomy / Thyroiditis / Factor IX / Thyroid Neoplasms / Thyrotropin / Carcinoma / Carcinoma, Papillary / Cell Transformation, Neoplastic Type of study: Prognostic study / Screening study Limits: Humans Language: English Journal: Journal of the Korean Surgical Society Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Values / Thyroid Gland / Thyroidectomy / Thyroiditis / Factor IX / Thyroid Neoplasms / Thyrotropin / Carcinoma / Carcinoma, Papillary / Cell Transformation, Neoplastic Type of study: Prognostic study / Screening study Limits: Humans Language: English Journal: Journal of the Korean Surgical Society Year: 2013 Type: Article