Deflazacort for Type-1 Autoimmune Hepatitis in a Korean Girl
Journal of Korean Medical Science
;
: 758-760, 2006.
Article
in English
| WPRIM
| ID: wpr-211994
ABSTRACT
Prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children. However, long-term use of corticosteroid is associated with the risk of steroid-induced toxicities, and this situation requires newer immuno-suppressive agents for the treatment of autoimmune hepatitis, especially in growing children. An 11-yr-old Korean girl with type-1 autoimmune hepatitis discontinued prednisolone due to toxicities, i.e., hirsutism, buffalo hump, and skin striae, and remained clinical and biochemical remission under replacement of deflazacort and ursodeoxycholic acid combination therapy. A follow-up liver biopsy after 19 months of deflazacort and ursodeoxycholic acid treatment showed histologic remission.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnenediones
/
Ursodeoxycholic Acid
/
Cholagogues and Choleretics
/
Treatment Outcome
/
Hepatitis, Autoimmune
/
Drug Therapy, Combination
/
Immunosuppressive Agents
/
Korea
Limits:
Child
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article
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