Surgical Treatment of Primary Neuroendocrine Tumors of the Liver
Korean Journal of Hepato-Biliary-Pancreatic Surgery
;
: 48-53, 2007.
Article
in Korean
| WPRIM
| ID: wpr-212141
ABSTRACT
PURPOSE:
Primary neuroendocrine tumor (PNET) of the liver is a very rare neoplasm. This study was conducted to analyze the clinical experience of 8 hepatic PNET cases.METHODS:
Four male and 4 female patients with a mean age of 50.4 +/- 9.5 years (range 37-64 years) underwent liver resection for hepatic PNET between January 1997 and December 2006. The diagnosis was confirmed histologically using light microscopy and immunohistochemistry in the absence of an alternative primary siteRESULTS:
Curative resection was achieved in 6 of the 8 patients, and 5 of the patients were alive and disease free after a mean follow-up period of 47.6 months. However, 3 patients died 3, 5 and 26 months after surgery due to multiple liver metastasis. A proliferative index of Ki67 appeared to indicate a significant risk factor for tumor recurrence. Additionally, recurrence occurred in 1 of the 6 patients that underwent curative resection during the follow-up period. Overall, both the 5-year recurrence rate and the 5-year survival rate were 50%.CONCLUSIONS:
Active exclusion of an extrahepatic primary site is essential for diagnosis of hepatic PNET. The primary treatment for PNET is curative liver resection, and a proliferative index of Ki67 appears to be a prognostic factor for tumor recurrence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Immunohistochemistry
/
Carcinoid Tumor
/
Survival Rate
/
Risk Factors
/
Follow-Up Studies
/
Neuroendocrine Tumors
/
Neuroectodermal Tumors, Primitive
/
Diagnosis
/
Liver
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Year:
2007
Type:
Article
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