G-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results / 대한뇌혈관외과학회지
Korean Journal of Cerebrovascular Surgery
;
: 235-240, 2006.
Article
in English
| WPRIM
| ID: wpr-212220
ABSTRACT
OBJECTIVE:
Acute stroke caused by cerebral artery occlusion or rupture is the most important vascular central nervous system disorder in Korea and remains a leading cause of death and disability despite significant clinical benefits after current treatment modalities. Therefore, it is crucial to develop new alternative therapeutic strategies. The most encouraging approach is directed towards cell transplantation into damaged regions. We discuss the ideal candidate for cell transplantation in current status and preliminary results of peripheral blood stem cells transplantation for acute stroke.METHODS:
Five patients with acute stroke (three patients with deep intracerebral hemorrhage and two patients with middle cerebral artery occlusion) underwent peripheral blood stem cells transplantation stereotactically.RESULTS:
Cell transplantation of three patients did not improve motor function recovery, as evidenced by NIHSS. However, interestingly, cell transplantation significantly increased CSF levels of vascular endothelial growth factor (VEGF).CONCLUSION:
Cell transplantation did correlate positively with elevated growth factor levels in CSF, but not with improved motor function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rupture
/
Stem Cells
/
Hematopoietic Stem Cells
/
Central Nervous System
/
Cerebral Arteries
/
Cerebral Hemorrhage
/
Cause of Death
/
Granulocyte Colony-Stimulating Factor
/
Cell Transplantation
/
Transplants
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Cerebrovascular Surgery
Year:
2006
Type:
Article
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