The dose of cyclophosphamide for treating paraquat-induced rat lung injury
The Korean Journal of Internal Medicine
;
: 420-427, 2013.
Article
in English
| WPRIM
| ID: wpr-212582
ABSTRACT
BACKGROUND/AIMS:
Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury.METHODS:
Adult male Sprague-Dawley rats were allocated into five groups control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The dimensions of lung lesions were determined using X-ray microtomography (micro-CT), and histological changes and cytokine levels were recorded.RESULTS:
The micro-CT results showed that 15 mg/kg CP was more effective than 1.5 mg/kg CP for treating PQ-induced lung injury. At a dose of 1.5 mg/kg, CP alleviated the histological evidence of inflammation and altered superoxide dismutase activity. Using 15 mg/kg CP reduced the elevated catalase activity and serum transforming growth factor (TGF)-beta1 level.CONCLUSIONS:
A CP dose of > 15 mg/kg is effective for reducing the severity of PQ-induced lung injury as determined by histological and micro-CT tissue examination, possibly by modulating antioxidant enzyme and TGF-beta1 levels.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraquat
/
Pulmonary Edema
/
Superoxide Dismutase
/
Severity of Illness Index
/
Catalase
/
Cytokines
/
Rats, Sprague-Dawley
/
Oxidative Stress
/
Inflammation Mediators
/
Cyclophosphamide
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS