The effect of pre-anesthetic administration of dexmedetomidine on the consumption of opioids in postoperative gynecologic patients
Anesthesia and Pain Medicine
;
: 37-41, 2017.
Article
in Korean
| WPRIM
| ID: wpr-21266
ABSTRACT
BACKGROUND:
This study was designed to assess whether pre-anesthetic administration of dexmedetomidine reduces the postoperative consumption of opioids, in patients receiving patient-controlled fentanyl after gynecological laparotomy.METHODS:
This was a prospective, randomized, double-blind, controlled study. Ten minutes before induction of anesthesia, 36 patients scheduled for elective gynecological laparotomy were assigned to receive either normal saline (group N) or dexmedetomidine 1 µg/kg (group D). A patient-controlled analgesia (PCA) device was used to administer fentanyl for the postoperative 24 h period. Cumulative fentanyl consumption and pain score were assessed at postoperative 30 min, 6 h and 24 h. Patient's satisfaction for pain control and other side effects (nausea, sedation score) were recorded for all corresponding time points.RESULTS:
There was no significant difference between the groups in cumulative fentanyl consumption (Group N 11.1 ± 3.2 µg/kg, Group D 10.3 ± 2.9 µg/kg, P value 0.706). The incidence of side-effects did not differ between the groups. Both groups showed similar blood pressure after anesthesia induction. However, 10 min after anesthesia induction, the heart rates in group D were significantly lower than group N (P = 0.0002).CONCLUSIONS:
In patients undergoing gynecological laparotomy, the pre-anesthetic administration of single loading dose dexmedetomidine (1 µg/kg) given 10 min before anesthesia induction did not reduce the PCA consumption of postoperative fentanyl or the pain score.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Blood Pressure
/
Passive Cutaneous Anaphylaxis
/
Fentanyl
/
Incidence
/
Prospective Studies
/
Analgesia, Patient-Controlled
/
Dexmedetomidine
/
Adrenergic alpha-2 Receptor Agonists
/
Heart Rate
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Anesthesia and Pain Medicine
Year:
2017
Type:
Article
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