The Effect of Haloperidol on Serum Levels of Interleukins in Schizophrenic Patients / 신경정신의학

ABSTRACT

OBJECTIVE: Altered interleukin(IL) regulation has been regarded as an additional proof that schizophrenia has a viral-autoimmunological background. However, it is possible that abnormalities of ILs may represent a neuroleptic artifact rather than a finding intrinsic to the disorder. Therefore, we studied the effect of haloperidol on serum IL level in schizophrenic patents. METHODS: We measured seam levels of IL-1beta, IL-2, and IL-6 using quantitative sandwich ELISA method at the day 0(before-medication), week 4 and week 8 in 20 male schizophrenic patents. RESULTS: There were no significant differences in serum IL-1beta, IL-2, and IL-6 levels between before medication and at either week 4 and week 8 artier haloperidol administration. CONCLUSIONS: These Bindings suggest that at least 8 weeks of haloperidol administration does not affect serum IL-19, IL-2 and IL-6 levels in male schizophrenics.