The Effects of Diazepam on the Carbachol Induced Contraction of the Isolated Rat Ileum / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 13-22, 1989.
Article
in Korean
| WPRIM
| ID: wpr-213595
ABSTRACT
To investigate the effect of diazepam on the contractility of the intestinal smooth muscle, longitudinal muscle strip isolated from rat ileum was prepared for myography in isolated organ bath. 1) Basal tone of ileal muscle was reduced by diazepam concentration-dependently. 2) Higher concentrations (30 and 100 microM) of diazepam inhibited (p<0.05, p<0.001) The carbachol-induced contraction in a concentration-dependent manner; but lower concentration of diazepam (10 microM) enhanced (p<0.05). 3) Histamine-induced contraction was inhibited by pretreatment with diazepam in a concentration-dependent manner. 4) Ca⁺⁺-induced tension recovery in calcium-free solution was inhibited in the presence of diazepam concentration-dependently. These results suggest diazepam reduces the contractility of the longitudinal muscle isolated from rat ileum via interference with influx of calcium into the muscle cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Baths
/
Carbachol
/
Calcium
/
Muscle Cells
/
Diazepam
/
Ileum
/
Muscle, Smooth
/
Myography
Limits:
Animals
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
1989
Type:
Article
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