Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
Experimental & Molecular Medicine
;
: e240-2016.
Article
in English
| WPRIM
| ID: wpr-213640
ABSTRACT
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phospholipases
/
Retinaldehyde
/
Blood Vessels
/
Endothelial Cells
/
Human Umbilical Vein Endothelial Cells
/
Hemorrhage
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2016
Type:
Article
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