Clinical Result of Prolonged Primary Chemotherapy in Retinoblastoma Patients
Korean Journal of Ophthalmology
;
: 35-43, 2003.
Article
in English
| WPRIM
| ID: wpr-213882
ABSTRACT
This study evaluated the effects of prolonged primary chemotherapy in retinoblastoma. The data for 27 eyes in 22 children who were treated for retinoblastoma with up to 13 cycles of primary chemotherapy was reviewed. The chemotherapy consisted of etoposide, vincristine, and either carboplatin or ifosfamide. In bilateral retinoblastoma, 1 eye was in each Ia, Ib, and Va, according to the Reese-Ellsworth classification, 2 in each IIa, IIIa, and IIIb, 4 in IIb, and 5 in IVa. Enucleation was performed in 1 in IIa and 1 in Va. In unilateral, 1 was in each IIa, IIIa, IVa, IVb, and Vb, and 4 in Va. Enucleation was performed in 8 with the exception of 1 in IIa. Complete regression was observed in 17 eyes (12 patients). There was no toxicity severe enough to delay treatment. Prolonged primary chemotherapy can be considered as an alternative treatment for retinoblastoma in III or less.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinoblastoma
/
Vincristine
/
Drug Administration Schedule
/
Eye Enucleation
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Carboplatin
/
Antineoplastic Agents, Alkylating
/
Retinal Neoplasms
/
Etoposide
Type of study:
Observational study
Limits:
Child, preschool
/
Humans
/
Infant
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2003
Type:
Article
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