Clinical Outcomes and Predictive Factors for Response after the First Course of Corticosteroid Therapy in Patients with Crohn's Disease
Gut and Liver
;
: 58-65, 2013.
Article
in English
| WPRIM
| ID: wpr-214010
ABSTRACT
BACKGROUND/AIMS:
This study sought to determine the natural course of Crohn's disease (CD) and identify predictors that could indicate responsiveness to corticosteroid (CS) therapy.METHODS:
Patients with active CD who were treated with oral CS at a single institution between August 1994 and February 2008 were retrospectively reviewed. The clinical outcomes at 1 month, 4 months, and 1 year after the treatment, as well as clinical and biochemical parameters at the time of CS initiation, were evaluated.RESULTS:
A total of 96 patients with CD were enrolled. In this study, 37 patients achieved complete remission (38.5%), 49 achieved partial remission (51.0%), and 10 (10.4%) showed no response at 1 month after the initiation of CS treatment. At 4 months and 1 year after treatment, 66 (69.5%) and 47 (56.6%) patients showed prolonged response, 22 (23.2%) and 20 (24.1%) showed steroid dependency, and 7 (7.4%) and 16 (19.3%) showed refractoriness, respectively. Nonstricturing and nonpenetrating behaviors and a lower CD activity index demonstrated clinical significance for mid-term or mid- and long-term steroid responses, respectively.CONCLUSIONS:
The short-term response rate to initial oral CS therapy in CD was considerably high, but responsiveness thereafter showed a tendency to decrease with time. Clinical parameters reflecting mild inflammation were associated with responsiveness after CS treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Steroids
/
Inflammatory Bowel Diseases
/
Crohn Disease
/
Retrospective Studies
/
Adrenal Cortex Hormones
/
Dependency, Psychological
/
Inflammation
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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