Prostate specific antigen in poorly differentiation tumors of bladder neck / 대한비뇨기과학회지

ABSTRACT

Prostate specific antigen (PSA) is located specifically in prostatic tissue and PSA immunostaining is objective and precise method for the detection of metastases of prostatic origin. When the differentiation of a tumor in the bladder neck` is very poor. the problem of distinguishing histologically between prostatic carcinoma invading the bladder neck and transitional cell carcinoma of the bladder wall occurs frequently. Establishing a prostatic origin for these neoplasms has important therapeutic implication. Seven cases with poorly differentiated carcinoma of the bladder neck were subjected to define the primary, either urothelial or prostatic origin with PSA immunostain. Two cases or the seven showed positive reaction for PSA. The origin of cancers was confirmed to be the prostate on clinical study and surgical intervention. Remaining five cases displayed negative results for PSA. These tumors all arose from the urinary bladder. Both sensitivity and specificity of PSA for prostate tumors were evaluated to be high in degree.