Narcolepsy: Clinical Feature, Diagnosis and Treatment / 수면정신생리
Sleep Medicine and Psychophysiology
;
: 63-68, 2010.
Article
in Korean
| WPRIM
| ID: wpr-214074
ABSTRACT
Narcolepsy is a central neurologic system disease. It begins early in life with disabling symptoms including excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucination and nocturnal sleep fragmentation. Patient with typical symptoms of narcolepsy is diagnosed by objective data from nocturnal polysomnography and multiple sleep latency tests. Narcolepsy is controlled with various medications. Nowadays, modafinil with favorable side effects profiles compared with traditional stimulant is mainly used. Gamma hydroxyl butyrate is effective in cataplexy. Cataplexy is also controlled with antidepressant such as Venlafaxine, SSRI, and TCA. As the knowledge of pathophysiology of narcolepsy expands, new treatment including immunological method, application of hypocretin and histamine systems have been tried.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sleep Deprivation
/
Benzhydryl Compounds
/
Neuropeptides
/
Butyrates
/
Histamine
/
Cataplexy
/
Polysomnography
/
Sleep Paralysis
/
Cyclohexanols
/
Intracellular Signaling Peptides and Proteins
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Sleep Medicine and Psychophysiology
Year:
2010
Type:
Article
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