Usefulness of Serum Cortisol in Assessment for the Severity of Community-Acquired Pneumonia / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 450-455, 2010.
Article
in Korean
| WPRIM
| ID: wpr-214080
ABSTRACT
BACKGROUND:
High cortisol levels are frequently observed in patients with severe infections are of prognostic value in sepsis. The aim of this study was to evaluate the clinical usefulness of serum cortisol in assessment for the severity of community-acquired pneumonia (CAP).METHODS:
This study analyzed the results of 52 CAP subjects admitted in Changwon Fatima Hospital between July 2008 to May 2010. Total serum cortisol, infection markers such as C-reactive protein (CRP), procalcitonin (PCT) and CURB (Confusion, Uremia, Respiratory rate, Blood pressure)-65 were examined retrospectively.RESULTS:
In clinically unstable subjects on admission day 4, baseline serum cortisol, CURB-65, and CRP were elevated significantly compared to those of stable subjects. Area under curve (AUC) of cortisol, CRP, and CURB-65 from ROC curves were 0.847, 0.783, and 0.724 respectively. In the subjects with serum cortisol > or =22.82 microg/dL, CRP, PCT, CURB-65 score, and mortality were significantly elevated.CONCLUSION:
These findings suggest that measurement of serum cortisol in early stage may provide helpful information in the assessment of CAP severity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Protein Precursors
/
Uremia
/
Severity of Illness Index
/
C-Reactive Protein
/
Calcitonin
/
Hydrocortisone
/
ROC Curve
/
Community-Acquired Infections
/
Sepsis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2010
Type:
Article
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