Long-Term Effects of ACE Inhibitors in Post-Tuberculosis Emphysema / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 418-425, 2010.
Article
in English
| WPRIM
| ID: wpr-214084
ABSTRACT
BACKGROUND:
Little is known about the long-term effects of angiotensin-converting enzyme (ACE) treatment on post-tuberculosis emphysema. This study evaluated the effects of ACE inhibition on cardiac function and gas exchange in patients with post-tuberculosis emphysema.METHODS:
At baseline and at 6 months after initiation of ACE inhibition therapy, patients underwent pulmonary function testing, arterial blood gas analysis, and echocardiography, both at rest and post exercise. Cardiac output (CO) and right ventricular ejection fraction (RVEF) were measured at those time points as well.RESULTS:
After ACE inhibition; resting and post-exercise RVEF (Mean+/-SEM, 61.5+/-1.0, 67.6+/-1.2%, respectively) were higher than at baseline (56.9+/-1.2, 53.5+/-1.7%). Resting and post-exercise CO (6.37+/-0.24, 8.27+/-0.34 L/min) were higher than at baseline (5.42+/-0.22, 6.72+/-0.24 L/min). Resting and post-exercise PaO2 (83.8+/-1.6, 74.0+/-1.2 mmHg, respectively) were also higher than at baseline (74.2+/-1.9, 66.6+/-1.6 mmHg). Post-exercise PaCO2 (46.3+/-1.1 mmHg) was higher than at baseline (44.9+/-1.1; Resting 42.8+/-0.8 vs. 42.4+/-0.9 mmHg). Resting and post-exercise A-a O2 gradient (12.4+/-1.4, 17.8+/-1.5 mmHg) were lower than at baseline (22.5+/-1.5, 26.9+/-1.6 mmHg).CONCLUSION:
In post-tuberculosis emphysema, RVEF and CO were augmented with a resultant increase in peripheral oxygen delivery after ACE inhibition. These findings suggest that an ACE inhibitor may have the potential to alleviate co-morbid cardiac conditions and benefit the patients with post-tuberculosis emphysema.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Pulmonary Emphysema
/
Respiratory Function Tests
/
Stroke Volume
/
Tuberculosis
/
Blood Gas Analysis
/
Angiotensin-Converting Enzyme Inhibitors
/
Echocardiography
/
Cardiac Output
/
Emphysema
Limits:
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2010
Type:
Article
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