Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
The World Journal of Men's Health
;
: 43-50, 2017.
Article
in English
| WPRIM
| ID: wpr-214130
ABSTRACT
PURPOSE:
This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS ANDMETHODS:
Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.RESULTS:
Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.CONCLUSIONS:
Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Superoxide Dismutase
/
Testis
/
Testosterone
/
Fibrosis
/
Rats, Sprague-Dawley
/
Guanosine Monophosphate
/
Oxidative Stress
/
Nitric Oxide Synthase
/
Models, Animal
/
Arterial Pressure
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2017
Type:
Article
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