Cytogenetic Analysis of 467 Cases of Amniocetesis / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 189-193, 1999.
Article
in Korean
| WPRIM
| ID: wpr-21414
ABSTRACT
OBJECTIVE:
The study of 467 cases of amniocentesis have been done at the department of Genetics, Taegu Cheil Hospital from Oct. 1997 to May 1999 for the purpose of analysis of abnormal karyotype according to the indication and age distribution,METHODS:
We collected amniotic fluid using 22G spinal needle and measured amniotic alphafetoprotein and acetylcholine esterase in supematant and performed cytogenetic analysis.RESULTS:
Positive Down screeing(positive triple test) was the most common indication of amniocentesis (61.5%) and abnormal karyotypes were 24 cases(5.1%) in 467 cases. Among 24 abnormal cases, 10 cases(2.1%) of 21 trisomy were observed. Abnormal karyotypes were most common in the group of abnormal ultrasonogram finding and the gmup of maternal age between 31 to 35 years old, which consists of 25% and 7.7% respectively.CONCLUSION:
More attention for the abnormal karyotype should be paid to the group of abnormal ultrasonogram finding and the group of maternal age between 31 to 35 years old as well as above 35 years old.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Trisomy
/
Acetylcholine
/
Ultrasonography
/
Maternal Age
/
Age Distribution
/
Cytogenetic Analysis
/
Cytogenetics
/
Abnormal Karyotype
/
Karyotype
/
Genetics
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS