Examination of the Effects of Vardenafil on Esophageal Function Using Multichannel Intraluminal Impedance and Manometry
Journal of Neurogastroenterology and Motility
;
: 399-405, 2012.
Article
in English
| WPRIM
| ID: wpr-21434
ABSTRACT
BACKGROUND/AIMS:
To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM).METHODS:
Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swallows and 10 viscous swallows in a seated position after fasting. Then, each subject was asked to ingest 50 mL distilled water or 10 mg vardenafil dissolved in 50 mL water, in a double-blind manner. After 25 minutes, the MII-EM study was repeated.RESULTS:
Eight men received vardenafil and eight subjects received water. Resting and residual lower esophageal sphincter pressures differed significantly only in the vardenafil group (from 18 +/- 6.7 to 6.6 +/- 5.3 mmHg, P < 0.001 and from 4.9 +/- 2.6 to 2.1 +/- 3.6 mmHg, P = 0.006, respectively). Mean distal esophageal amplitude decreased significantly only in the vardenafil group (from 86.7 +/- 41.6 to 34.0 +/- 38.0 mmHg, P < 0.05). Complete bolus transits of liquid and viscous meals decreased significantly only after vardenafil ingestion (from 80.2% +/- 13.8% to 49.4% +/- 27.9%, P < 0.05 and from 72.8% +/- 33.6% to 21.5% +/- 29.0%, P = 0.01, respectively).CONCLUSIONS:
Vardenafil decreased esophageal bolus transit in the seated position, despite decreased lower esophageal sphincter pressure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperazines
/
Sulfones
/
Triazines
/
Water
/
Fasting
/
Electric Impedance
/
Esophageal Sphincter, Lower
/
Swallows
/
Eating
/
Meals
Type of study:
Controlled clinical trial
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2012
Type:
Article
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