Age-Related CD26 Expression in Circulating T Cells in Peripheral Blood / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 174-180, 2005.
Article
in Korean
| WPRIM
| ID: wpr-214446
ABSTRACT
BACKGROUND:
Cytokine response changes with ageing. CD26 is known as an operational marker for Th1 pathway. In this study we investigated the possibility of CD26 as a practical marker for immunosenescence, Th1 or Th2 polarization.METHODS:
We studied 99 subjects from 4 groups divided by age (thirties and sixties) and by hepatitis B. CD26 expression in T cells in peripheral blood was investigated by 3 color flow cytometry. Especially, CD26 expression in activated (HLA-DR+) T cells was compared among each group.RESULTS:
CD26 expression in total T cells had the trend toward a decrease with ageing and decreased significantly especially in Ts cells (from 45.9+/-11.3% to 37.5+/-12.4%, P<0.05). Regardless of hepatitis B, CD26 expression in activated Th cells was not significantly different between the two age groups. HLA-DR expression in total T cells had the trend toward an increase in the elderly or hepatitis B and the dominant T cell subset responsible for this increase was Ts cell subset in the elderly and was Th cell subset in hepatitis B.CONCLUSIONS:
We could not find the possibility of CD26 as a practical marker for immunosenescence reflecting Th1 polarization in activated Th cells. But CD26 or HLA-DR expression in total T cells had the trend to change with ageing and the change in Ts cells was more dominant than in Th cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes
/
HLA-DR Antigens
/
Flow Cytometry
/
Hepatitis B
Limits:
Aged
/
Humans
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2005
Type:
Article
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