A Case of Infectious Mononucleosis-like Syndrome Induced by Sulfasalazine / 대한내과학회지
Korean Journal of Medicine
;
: 712-716, 2005.
Article
in Korean
| WPRIM
| ID: wpr-214454
ABSTRACT
Sulfasalazine, one of disease modifying anti-rheumatic drugs, is widely used in various rheumatic diseases. Very rarely, sulfasalazine causes drug-associated hypersensitivity syndrome that resembles infectious mononucleosis. Clinical signs include fever, lymphadenopathy, maculopapular skin rash and multivisceral involvement which appear 2 to 5 weeks after administration of drug. Atypical lymphocytosis, liver dysfunction and splenomegaly are also frequently observed. Severe infectious mononucleosis-like syndrome in sulfasalazine treated patients can be caused by reactivation of viruses such as human herpes virus-6, that often result in hypersensitivity syndrome. We report a case of patient who developed infectious mononucleosis-like syndrome after administration of sulfasalazine for the treatment of rheumatoid arthritis. This case warrents careful observation for infectious mononucleosis-like syndrome after sulfasalazine treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Sulfasalazine
/
Splenomegaly
/
Rheumatic Diseases
/
Antirheumatic Agents
/
Exanthema
/
Fever
/
Hypersensitivity
/
Infectious Mononucleosis
/
Liver Diseases
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2005
Type:
Article
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