Effects of Prenatal Exposure to Nitric Oxide Synthase Inhibitor on MK-801-Elicited Behavioral Sensitivity in Postnatal Rats / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 13-18, 2007.
Article
in Korean
| WPRIM
| ID: wpr-214495
ABSTRACT
OBJECTIVES:
The aim of the present study was to investigate the role of prenatal exposure to NOS (nitric oxide synthase) inhibitor during the 3rd trimester of pregnancy on MK-801-elicited behavioral sensitivity in postnatal juvenile rats and the effect of an antipsychotic drug on the change in MK-801-elicited behavioral sensitivity in an attempt to elucidate the participation of NO (nitric oxide) in the pathophysiology of schizophrenia.METHODS:
L-NA (N-nitro-L-arginine, 25 mg/kg, 40 mg/kg) was injected intraperitoneally in pregnant Sprague-Dawley rats during the 3rd trimester of pregrancy. On postnatal day 35, MK-801-elicited behavioral sensitivity was measured using Neurovision Analysis (automatic motor analysis program). Animals were pretreated with haloperidol or clozapine as a antipsychotic drug before administration of MK-801. Statistical tests of drug effects were performed using ANOVA. A value producing p<0.05 was considered to be significant.RESULTS:
MK-801-elicited locomotor activity was significantly increased with prenatal exposure to L-NA in postnatal rats. The change in MK-801-elicited behavioral sensitivity was significantly diminished by pretreatment with haloperidol and clozapine.CONCLUSION:
These findings suggest that NO may in part play an important role in neurodevelopment in that prenatal exposure to NOS inhibitor can influence MK-801-elicited behavioral sensitivity in postnatal rats. These results also indicate that the neurodevelopmental abnormality may predispose schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Dizocilpine Maleate
/
Clozapine
/
Rats, Sprague-Dawley
/
Nitric Oxide Synthase
/
Haloperidol
/
Motor Activity
/
Nitric Oxide
Type of study:
Diagnostic study
Limits:
Animals
/
Pregnancy
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2007
Type:
Article
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