Apolipoprotein E Polymorphism and Cognitive Function Change of the Elderly in a Rural Area, Korea / 예방의학회지
Journal of Preventive Medicine and Public Health
;
: 261-266, 2009.
Article
in Korean
| WPRIM
| ID: wpr-214619
ABSTRACT
OBJECTIVES:
The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline.METHODS:
Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 (1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed.RESULTS:
The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8-year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment.CONCLUSIONS:
The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Polymorphism, Genetic
/
Cognition
/
Cognition Disorders
/
Korea
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Preventive Medicine and Public Health
Year:
2009
Type:
Article
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