CYP19 Gene Polymorphism in Patients with Endometriosis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 726-731, 2005.
Article
in Korean
| WPRIM
| ID: wpr-215519
ABSTRACT
OBJECTIVE:
To explore the association of the CYP19 gene polymorphism with the risk of endometriosis.METHODS:
Two hundred seventy-nine women with surgically or histologically diagnosed endometriosis of stages I-IV (ASRM, 1997) were recruited, and two hundred eighteen patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. We analysed the frequency and distribution of a TTTA repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene.RESULTS:
Six alleles of the CYP19 gene tetranucleotide repeat polymorphism were found insubjects:
from 7 repeats to 13 repeats except 9 repeats. There was no statistically significant difference in the allele distribution of tetranucleotide repeat polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. Also there was no statistically significant difference in the 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls.CONCLUSION:
These results suggest that tetranucleotide repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism of the CYP19 gene are not associated with the risk endometriosis in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aromatase
/
Introns
/
Laparoscopy
/
Microsatellite Repeats
/
Endometriosis
/
Alleles
/
Laparotomy
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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