A Case of 5-fluorouracil-induced Phototoxicity / 대한피부과학회지
Korean Journal of Dermatology
;
: 1364-1366, 2006.
Article
in Korean
| WPRIM
| ID: wpr-215676
ABSTRACT
5-fluorouracil (5-FU) is an antimetabolite which prevents thymine synthesis and suppresses the utilization of preformed uracil. A variety of cutaneous reactions have been reported with the use of systemic 5-FU, the most common being photosensitivity. We report a case of 5-FU induced phototoxicity in a 73-year-old male. The patient had tender and slightly pruritic scaly and crusted erythema on sun-exposed areas. A biopsy revealed necrotic keratinocytes with epidermal degeneration. After the cessation of 5-FU, the skin lesions showed a marked improvement, and there was no further photosensitivity to the skin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Thymine
/
Uracil
/
Biopsy
/
Keratinocytes
/
Dermatitis, Phototoxic
/
Erythema
/
Fluorouracil
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2006
Type:
Article
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