A Rare Case of Transformation of Childhood Myelodysplastic Syndrome to Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
;
: 130-135, 2013.
Article
in English
| WPRIM
| ID: wpr-216010
ABSTRACT
Transformation of MDS into ALL during childhood is extremely rare. We report a rare case of an 8-yr-old girl who presented with refractory cytopenia of childhood (RCC) that transformed into ALL only 3 months after the diagnosis of childhood MDS. Although no cytogenetic abnormalities were observed in conventional karyotype and FISH analysis, we found several deletions on chromosomes 5q, 12q, 13q, and 22q. Partial homozygous deletion of the RB1 gene was observed on microarray analysis, with the bone marrow specimen diagnosed as ALL. This is the first case report of transformation of ALL from childhood MDS in Korea. We also compared the clinical, cytological, and cytogenetic features of 4 previously reported childhood MDS cases that transformed into ALL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Myelodysplastic Syndromes
/
Bone Marrow Cells
/
Cell Transformation, Neoplastic
/
Retinoblastoma Protein
/
Chromosome Aberrations
/
In Situ Hybridization, Fluorescence
/
Gene Deletion
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Karyotyping
Limits:
Child
/
Female
/
Humans
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2013
Type:
Article
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