Potential Serum Markers for Monitoring the Progression of Hepatitis B Virus-Associated Chronic Hepatic Lesions to Liver Cirrhosis
Gut and Liver
;
: 665-671, 2015.
Article
in English
| WPRIM
| ID: wpr-216102
ABSTRACT
BACKGROUND/AIMS:
To screen for serum protein/peptide biomarkers of hepatitis B virus (HBV)-associated chronic hepatic lesions in an attempt to profile the progression of HBV-associated chronic hepatic lesions using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) techniques.METHODS:
Using SELDI-TOF MS, serum protein/peptide profiles on the CM10 ProteinChip arrays were obtained from a training group including 26 HBV-associated hepatocellular carcinoma patients with liver cirrhosis (LC), 30 HBV-associated LC patients, 85 patients at different stages of liver fibrosis, and 30 asymptomatic HBV carriers. The most valuable SELDI peak for predicting the progression to LC in HBV-infected patients was identified.RESULTS:
A SELDI peak of M/Z 5805 with value for predicting LC in HBV-infected patients was found and was identified as a peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1.CONCLUSIONS:
The peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1 with M/Z 5805, may be a serological biomarker for progression to LC in HBV-infected patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biomarkers
/
Hepatitis B virus
/
Carcinoma, Hepatocellular
/
Disease Progression
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Hepatitis B, Chronic
/
Protein Array Analysis
/
Liver Cirrhosis
/
Liver Neoplasms
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2015
Type:
Article
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