The Efficacy of a Modified Chronomodulated Infusion of Oxaliplatin, 5-Fluorouracil and Leucovorin in Advanced Colorectal Cancer (Preliminary Data) / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 199-204, 2004.
Article
in English
| WPRIM
| ID: wpr-216205
ABSTRACT
PURPOSE:
To determine the efficacy and tolerability of a modified chronomodulated infusion of oxaliplatin, 5-fluorouracil (5-FU) and leucovorin in the treatment of advanced colorectal cancer. MATERIALS ANDMETHODS:
Sixteen patients with relapsed or metastatic colorectal cancer were treated with an intravenous infusion of oxaliplatin 25 mg/m(2), 5-FU 700 mg/m(2) and leucovorin 20 mg/m(2) on days 1 to 5. The infusion of oxaliplatin was chronomodulated with a peak delivery rate at 16 00 p.m., with 5-FU infused constantly overnight. Each course was repeated every 21 days.RESULTS:
The response rate was 38.5% (95% confidence interval [CI], 13.9% to 68.4%) in the 13 measurable patients, including 1 complete response (7.7%) and 4 partial responses (30.8%). Five patients (38.5%) had a stable disease and 3 (23.0%) a progressive disease. Three patients without a measurable lesion had improved status. The median time to progression and overall survival were 29 weeks and 85 weeks, respectively. Grade 3 thrombocytopenia occurred in 2.5% (2 cycles) and grade 3 vomiting in 12.5% (2 patients). Anorexia, stomatitis, diarrhea, pruritus, alopecia and peripheral neuropathy were mild and tolerable.CONCLUSION:
The modified chronomodulated infusion of oxaliplatin, 5-FU and leucovorin is effective and tolerable, but the number of patients was too small. Further study will be needed to confirm the efficacy of this regimen with a larger population of patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Stomatitis
/
Thrombocytopenia
/
Vomiting
/
Infusions, Intravenous
/
Colorectal Neoplasms
/
Anorexia
/
Leucovorin
/
Peripheral Nervous System Diseases
/
Chronotherapy
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2004
Type:
Article
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