Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 187-191, 2004.
Article
in English
| WPRIM
| ID: wpr-216207
ABSTRACT
PURPOSE:
To evaluate the relationship between treatment failure and COX-2 expression in nasopharyngeal cancer patients treated with chemotherapy and radiotherapy. MATERIALS ANDMETHODS:
The subjects of this study were 22 nasopharyngeal cancer patients. The patients were treated with neoadjuvant chemotherapy, followed by radiotherapy, or with radiotherapy alone. The formalin- fixed, paraffin- embedded tissues of 11 patients who developed a locoregional recurrence (n=7) or distant metastasis (n=4) were compared with those of 11 disease free patients. Prognostic factors, including histological type, stage, radiation dose and chemotherapy, were well balanced between the two groups. The COX-2 expression was determined immunohistochemically.RESULTS:
COX-2 expression was stronger in the patients with a locoregional recurrence or distant metastasis than in those free of disease. The COX-2 distribution scores of the control group were as follows 0 in 7, 1 in 2 and 2 in 2 patients. In the recurrence group, the scores were as follows; 0 in 3, 1 in 1, 2 in 2 and 3 in 5 patients. COX-2 expression was shown to have a statistically significant influence on the treatment failure by the Mann-Whitney U test (p=0.024) and Mantel-Haenszel Chi-Square test (p=0.018). It also significantly influenced the treatment failure when an analysis was performed within patients with a undifferentiated histology (p=0.039 by the Mann- Whitney U test, p=0.037 by the Mantel-Haenszel Chi- Square test).CONCLUSION:
COX-2 expression is believed to be one of the important factors associated with a locoregional recurrence or distant metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Recurrence
/
Nasopharyngeal Neoplasms
/
Prostaglandin-Endoperoxide Synthases
/
Treatment Failure
/
Drug Therapy
/
Cyclooxygenase 2
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2004
Type:
Article
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